Reactome | Phosphorylation of Cdc25C at Ser216 by CHEK2

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Phosphorylation of Cdc25C at Ser216 by CHEK2 Show undefined attributes

authored	[InstanceEdit:212506] Sanchez, Y, 2004-02-10 21:59:11
catalystActivity	[CatalystActivity:75808] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00
dbId	75809
displayName	Phosphorylation of Cdc25C at Ser216 by CHEK2
edited	[InstanceEdit:111978] Matthews, L, 2004-03-22 22:00:00
eventOf	[Pathway:R-HSA-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9029987] p-S216-CDC25C translocates to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-69741] CDC25C [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:210722] Dual phosphorylation controls Cdc25 phosphatases and mitotic entry [LiteratureReference:8986060] Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	Phosphorylation of Cdc25C at Ser216 by CHEK2
orthologousEvent	[Reaction:R-SCE-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Saccharomyces cerevisiae [Reaction:R-SPO-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Schizosaccharomyces pombe [Reaction:R-DDI-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Dictyostelium discoideum [Reaction:R-CEL-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Caenorhabditis elegans [Reaction:R-DME-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Drosophila melanogaster [Reaction:R-SSC-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Sus scrofa [Reaction:R-BTA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Bos taurus [Reaction:R-CFA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Canis familiaris [Reaction:R-RNO-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Rattus norvegicus [Reaction:R-MMU-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-156496] p-S216-CDC25C [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6798268] TP53 and E2F4 inhibit CDC25C expression - Homo sapiens [Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165074] Manfredi, James J
revised	[InstanceEdit:210723] Matthews, L, 2008-01-15 13:54:21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75809
summation	[Summation:210725] Cdc25C is negatively regulated by phosphorylation on Ser 21...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9029987] p-S216-CDC25C translocates to the cytosol
(hasEvent)	[Pathway:R-HSA-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex