Reactome | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Show undefined attributes

authored	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
created	[InstanceEdit:77574] Matthews, L, 2003-10-31 01:05:00
crossReference	[DatabaseIdentifier:12325450] BioModels Database:BIOMD0000000939
dbId	75035
displayName	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
eventOf	[Pathway:R-HSA-69473] G2/M DNA damage checkpoint - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Homo sapiens [BlackBoxEvent:R-HSA-9029987] p-S216-CDC25C translocates to the cytosol - Homo sapiens [Reaction:R-HSA-75016] Association of p-S216-CDC25C with 14-3-3 proteins - Homo sapiens [Reaction:R-HSA-75028] Phosphorylation of Wee1 kinase by Chk1 - Homo sapiens [Reaction:R-HSA-170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes - Homo sapiens
isInDisease	false
isInferred	false
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
orthologousEvent	[Pathway:R-SCE-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Saccharomyces cerevisiae [Pathway:R-SPO-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Schizosaccharomyces pombe [Pathway:R-DDI-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Dictyostelium discoideum [Pathway:R-CEL-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Caenorhabditis elegans [Pathway:R-DME-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Drosophila melanogaster [Pathway:R-XTR-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Xenopus tropicalis [Pathway:R-DRE-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Danio rerio [Pathway:R-SSC-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Sus scrofa [Pathway:R-BTA-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Bos taurus [Pathway:R-CFA-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Canis familiaris [Pathway:R-RNO-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Rattus norvegicus [Pathway:R-MMU-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Mus musculus
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75035
summation	[Summation:75036] DNA damage induced activation of the checkpoint kinases Chk...

Referrals

(hasEvent)

[Pathway:R-HSA-69473] G2/M DNA damage checkpoint