Reactome | alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2

Schema > Reaction > Entries

alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 Show undefined attributes

catalystActivity	[CatalystActivity:70798] acyl-CoA dehydrogenase activity of ACADSB tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643583] acyl-CoA dehydrogenase activity of ACADSB tetramer [mitochondrial matrix] Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism
category	transition
compartment	[Compartment:5460] mitochondrial matrix
dbId	70800
displayName	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2
eventOf	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70830] tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-70718] 2MBUT-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70801] Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism [LiteratureReference:70813] 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2
orthologousEvent	[Reaction:R-DDI-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Dictyostelium discoideum [Reaction:R-CEL-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Caenorhabditis elegans [Reaction:R-DME-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Drosophila melanogaster [Reaction:R-GGA-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Gallus gallus [Reaction:R-XTR-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Xenopus tropicalis [Reaction:R-SSC-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Sus scrofa [Reaction:R-BTA-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Bos taurus [Reaction:R-CFA-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Canis familiaris [Reaction:R-RNO-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Rattus norvegicus [Reaction:R-MMU-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Mus musculus
output	[SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] [SimpleEntity:R-ALL-70799] tiglyl-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70713] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70800
summation	[Summation:178469] Mitochondrial 2-methyl branched chain acyl-CoA dehydrogenase...

Referrals

(hasEvent)	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-HSA-70830] tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA

Cite Us!