Reactome | GOT2 dimer deaminates L-Asp

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GOT2 dimer deaminates L-Asp Show undefined attributes

catalystActivity	[CatalystActivity:70595] L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643893] L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix] Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:11881194] Rhea:21825
dbId	70596
displayName	GOT2 dimer deaminates L-Asp
eventOf	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113553] L-Asp [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199763] The primary structure of mitochondrial aspartate aminotransferase from human heart
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	GOT2 dimer deaminates L-Asp aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
orthologousEvent	[Reaction:R-SCE-70596] GOT2 dimer deaminates L-Asp - Saccharomyces cerevisiae [Reaction:R-SPO-70596] GOT2 dimer deaminates L-Asp - Schizosaccharomyces pombe [Reaction:R-DDI-70596] GOT2 dimer deaminates L-Asp - Dictyostelium discoideum [Reaction:R-CEL-70596] GOT2 dimer deaminates L-Asp - Caenorhabditis elegans [Reaction:R-DME-70596] GOT2 dimer deaminates L-Asp - Drosophila melanogaster [Reaction:R-GGA-70596] GOT2 dimer deaminates L-Asp - Gallus gallus [Reaction:R-XTR-70596] GOT2 dimer deaminates L-Asp - Xenopus tropicalis [Reaction:R-DRE-70596] GOT2 dimer deaminates L-Asp - Danio rerio [Reaction:R-SSC-70596] GOT2 dimer deaminates L-Asp - Sus scrofa [Reaction:R-BTA-70596] GOT2 dimer deaminates L-Asp - Bos taurus [Reaction:R-CFA-70596] GOT2 dimer deaminates L-Asp - Canis familiaris [Reaction:R-RNO-70596] GOT2 dimer deaminates L-Asp - Rattus norvegicus [Reaction:R-MMU-70596] GOT2 dimer deaminates L-Asp - Mus musculus
output	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70596
summation	[Summation:178478] Mitochondrial glutamate oxaloacetate transaminase 2 (asparta...

Referrals

(hasEvent)

[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism