Reactome | D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP

Schema > Reaction > Entries

D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP Show undefined attributes

catalystActivity	[CatalystActivity:70466] 6-phosphofructokinase activity of PFK tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644014] 6-phosphofructokinase activity of PFK tetramer [cytosol] Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:11880474] Rhea:16110
dbId	70467
displayName	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
eventOf	[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent	[Reaction:R-HSA-71496] D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29512] Fru(6)P [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71622] Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet [LiteratureReference:141464] Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency [LiteratureReference:141470] Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system [LiteratureReference:141529] Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system [LiteratureReference:70305] Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
orthologousEvent	[Reaction:R-SCE-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Saccharomyces cerevisiae [Reaction:R-SPO-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Schizosaccharomyces pombe [Reaction:R-CEL-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Caenorhabditis elegans [Reaction:R-DME-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Drosophila melanogaster [Reaction:R-GGA-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Gallus gallus [Reaction:R-DRE-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Danio rerio [Reaction:R-SSC-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Sus scrofa [Reaction:R-BTA-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Bos taurus [Reaction:R-CFA-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Canis familiaris [Reaction:R-RNO-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Rattus norvegicus [Reaction:R-MMU-70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-30014] F1,6PP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-70471] alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate - Homo sapiens [Reaction:R-HSA-6799604] GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-71504] Positive regulation by 'AMP [cytosol]' [PositiveRegulation:R-HSA-71505] Positive regulation by 'ADP [cytosol]' [PositiveRegulation:R-HSA-71506] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [NegativeRegulation:R-HSA-71507] Negative regulation by 'ATP [cytosol]' [NegativeRegulation:R-HSA-71508] Negative regulation by 'CIT [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70467
summation	[Summation:71462] Cytosolic phosphofructokinase 1 catalyzes the reaction of fr...

Referrals

(hasEvent)	[Pathway:R-HSA-70171] Glycolysis
(precedingEvent)	[Reaction:R-HSA-71496] D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate

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