Reactome | Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:69755] cyclin-dependent protein serine/threonine kinase activity of CCNA2:p-T161-CDK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
dbId	69756
displayName	Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
eventOf	[Pathway:R-HSA-170145] Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [GenomeEncodedEntity:R-HSA-617374] G2/M transition proteins [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77497] Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [GenomeEncodedEntity:R-HSA-617371] Cyclin A2:Cdk2 phosphorylated G2/M transition protein [nucleoplasm] [GenomeEncodedEntity:R-HSA-69753] phospho-G2/M transition protein [nucleoplasm]
precedingEvent	[Reaction:R-HSA-170158] Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69756
summation	[Summation:179075] At the beginning of this reaction, 1 molecule of 'ATP', and ...

(hasEvent)

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