Reactome | RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain

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RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain Show undefined attributes

authored	[InstanceEdit:6810224] May, Bruce, 2015-11-08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6810237] May, Bruce, 2015-11-16
dbId	6810235
displayName	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain
edited	[InstanceEdit:6810224] May, Bruce, 2015-11-08
eventOf	[Pathway:R-HSA-6807505] RNA polymerase II transcribes snRNA genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6814549] Pre-snRNA transcript initiation, Integrator binding, LEC binding - Homo sapiens
input	[Complex:R-HSA-6810221] RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6810227] RPAP2 [nucleoplasm] [Complex:R-HSA-6814908] RPRD1A,B:RPRD1A,B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6814906] RPRD2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6810207] Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes [LiteratureReference:6814871] Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B [LiteratureReference:6814866] RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain
orthologousEvent	[Reaction:R-SCE-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Saccharomyces cerevisiae [Reaction:R-GGA-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Gallus gallus [Reaction:R-XTR-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Xenopus tropicalis [Reaction:R-SSC-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Sus scrofa [Reaction:R-BTA-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Bos taurus [Reaction:R-CFA-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Canis familiaris [Reaction:R-RNO-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Rattus norvegicus [Reaction:R-MMU-6810235] RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain - Mus musculus
output	[Complex:R-HSA-6810229] RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6810233] CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8858395] Hernandez, Nouria, 2016-02-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6810235
summation	[Summation:6814935] The protein phosphatase RPAP2 binds RNA polymerase II phosph...

Referrals

(hasEvent)	[Pathway:R-HSA-6807505] RNA polymerase II transcribes snRNA genes
(precedingEvent)	[BlackBoxEvent:R-HSA-6814549] Pre-snRNA transcript initiation, Integrator binding, LEC binding