Reactome | ATP7A transports cytosolic Cu2+ to phagosomal lumen

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ATP7A transports cytosolic Cu2+ to phagosomal lumen Show undefined attributes

authored	[InstanceEdit:6803156] Shamovsky, Veronica, 2015-10-05
catalystActivity	[CatalystActivity:6803542] P-type divalent copper transporter activity of ATP7A:PDZD11 [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:1222282] phagocytic vesicle lumen [Compartment:1222693] phagocytic vesicle membrane
created	[InstanceEdit:6803543] Shamovsky, Veronica, 2015-10-07
dbId	6803545
displayName	ATP7A transports cytosolic Cu2+ to phagosomal lumen
edited	[InstanceEdit:8935852] Shamovsky, Veronica, 2016-08-15
eventOf	[Pathway:R-HSA-6803544] Ion influx/efflux at host-pathogen interface - Homo sapiens
input	[Complex:R-HSA-3697875] ATOX1:Cu1+ [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8864786] Copper at the front line of the host-pathogen battle [LiteratureReference:8864765] The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens [LiteratureReference:8864787] Copper homeostasis at the host-pathogen interface
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	ATP7A transports cytosolic Cu2+ to phagosomal lumen Copper export from cells by copper-transporting ATPase1
orthologousEvent	[Reaction:R-CFA-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Canis familiaris [Reaction:R-GGA-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Gallus gallus [Reaction:R-XTR-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Xenopus tropicalis [Reaction:R-DRE-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Danio rerio [Reaction:R-SSC-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Sus scrofa [Reaction:R-RNO-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Rattus norvegicus [Reaction:R-MMU-6803545] ATP7A transports cytosolic Cu2+ to phagosomal lumen - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-3697884] ATOX1 [cytosol] [SimpleEntity:R-ALL-6803540] Cu1+ [phagocytic vesicle lumen] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933035] Hains, David S, 2016-08-02 [InstanceEdit:8867536] Jupe, Steve, 2016-04-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6803545
summation	[Summation:8864801] Copper is an essential cofactor of key metabolic enzymes (Li...

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(hasEvent)

[Pathway:R-HSA-6803544] Ion influx/efflux at host-pathogen interface