Reactome | Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER

Schema > Reaction > Entries

Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER Show undefined attributes

authored	[InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6782209] DNA-directed DNA polymerase activity of TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782207] Orlic-Milacic, Marija, 2015-06-05
dbId	6782208
displayName	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-6782210] Gap-filling DNA repair synthesis and ligation in TC-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-6782227] Ligation of newly synthesized repair patch to incised DNA in TC-NER - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-HSA-6782222] TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690036] Coordination of dual incision and repair synthesis in human nucleotide excision repair [LiteratureReference:5690482] Replication protein A safeguards genome integrity by controlling NER incision events [LiteratureReference:5690489] Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells [LiteratureReference:6782218] Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
orthologousEvent	[Reaction:R-PFA-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Plasmodium falciparum [Reaction:R-SCE-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Saccharomyces cerevisiae [Reaction:R-SPO-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Schizosaccharomyces pombe [Reaction:R-DDI-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Dictyostelium discoideum [Reaction:R-CEL-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Caenorhabditis elegans [Reaction:R-DME-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Drosophila melanogaster [Reaction:R-GGA-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Gallus gallus [Reaction:R-XTR-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Xenopus tropicalis [Reaction:R-SSC-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Sus scrofa [Reaction:R-BTA-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Bos taurus [Reaction:R-CFA-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Canis familiaris [Reaction:R-RNO-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Rattus norvegicus [Reaction:R-MMU-6782208] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER - Mus musculus
output	[SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [Complex:R-HSA-6782220] TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782208
summation	[Summation:6782215] In transcription-coupled nucleotide excision repair (TC-NER)...

Referrals

(hasEvent)	[Pathway:R-HSA-6782210] Gap-filling DNA repair synthesis and ligation in TC-NER
(precedingEvent)	[Reaction:R-HSA-6782227] Ligation of newly synthesized repair patch to incised DNA in TC-NER

Cite Us!