Reactome | p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane]

Schema > Complex > Entries

p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9653109] p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers - Homo sapiens [Reaction:R-HSA-5672969] Phosphorylation of RAF - Homo sapiens
created	[InstanceEdit:5672732] Rothfels, Karen, 2015-02-05
dbId	5672733
displayName	p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane]
hasComponent	[DefinedSet:R-HSA-5672731] dephosphorylated "receiver" RAF/KSR1 [cytosol] [Complex:R-HSA-5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Mus musculus [Complex:R-RNO-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Rattus norvegicus [Complex:R-CFA-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Canis familiaris [Complex:R-BTA-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Bos taurus [Complex:R-SSC-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Sus scrofa [Complex:R-GGA-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Gallus gallus [Complex:R-DME-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Caenorhabditis elegans [Complex:R-PFA-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] - Plasmodium falciparum
isChimeric	false
name	p21 RAS:GTP:homo/heterodimerized RAF complex
producedByEvent	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5672733

Referrals

(normalEntity)	[EntityFunctionalStatus:6802860] gain_of_function of BRAF/RAF fusion dimers [cytosol] [EntityFunctionalStatus:9656202] gain_of_function of p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] [EntityFunctionalStatus:6802894] gain_of_function of mutant RAS:inactive BRAF:RAF1 [plasma membrane] [EntityFunctionalStatus:6802872] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane] [EntityFunctionalStatus:6802864] gain_of_function of RAS mutants:GTP:RAF homo/heterodimer [plasma membrane]
(input)	[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers [Reaction:R-HSA-5672969] Phosphorylation of RAF
(output)	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
(hasComponent)	[Complex:R-HSA-9653109] p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane]

© 2024 Reactome

Cite Us!