Reactome | CD70 binds CD27

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CD70 binds CD27 Show undefined attributes

authored	[InstanceEdit:5669069] Jassal, Bijay, 2015-01-30
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5669069] Jassal, Bijay, 2015-01-30
dbId	5669024
displayName	CD70 binds CD27
edited	[InstanceEdit:5669069] Jassal, Bijay, 2015-01-30
eventOf	[Pathway:R-HSA-5669034] TNFs bind their physiological receptors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5666994] CD27 [plasma membrane] [Complex:R-HSA-5675989] CD70 homotrimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5669060] The cloning of CD70 and its identification as the ligand for CD27 [LiteratureReference:5669072] The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family [LiteratureReference:5669053] CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia [LiteratureReference:5669049] Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	CD70 binds CD27
orthologousEvent	[Reaction:R-SSC-5669024] CD70 binds CD27 - Sus scrofa [Reaction:R-BTA-5669024] CD70 binds CD27 - Bos taurus [Reaction:R-CFA-5669024] CD70 binds CD27 - Canis familiaris [Reaction:R-MMU-5669024] CD70 binds CD27 - Mus musculus
output	[Complex:R-HSA-5669095] CD27:CD70 homotrimer [plasma membrane]
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5669024
summation	[Summation:5669022] The CD70 antigen (CD70) is a cytokine that is found on the s...

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[Pathway:R-HSA-5669034] TNFs bind their physiological receptors