Reactome | SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA

Schema > Reaction > Entries

SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity	[CatalystActivity:5654990] ATP hydrolysis activity of NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5654983] Orlic-Milacic, Marija, 2014-12-04
dbId	5654989
displayName	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-110320] Translesion Synthesis by POLH - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5654991] NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5655020] DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage [LiteratureReference:5655028] DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks [LiteratureReference:5653648] Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis [LiteratureReference:1169373] Proteomic identification of proteins conjugated to ISG15 in mouse and human cells
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
orthologousEvent	[Reaction:R-SCE-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Saccharomyces cerevisiae [Reaction:R-SPO-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Schizosaccharomyces pombe [Reaction:R-CEL-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Caenorhabditis elegans [Reaction:R-DME-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Drosophila melanogaster [Reaction:R-GGA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Gallus gallus [Reaction:R-XTR-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Xenopus tropicalis [Reaction:R-DRE-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Danio rerio [Reaction:R-SSC-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Sus scrofa [Reaction:R-BTA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Bos taurus [Reaction:R-CFA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Canis familiaris [Reaction:R-RNO-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Rattus norvegicus [Reaction:R-MMU-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5654988] NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-110287] POLH [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5654985] SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654989
summation	[Summation:5655111] The ATP-ase activity of VCP facilitates release of POLH (DNA...

Referrals

(hasEvent)

[Pathway:R-HSA-110320] Translesion Synthesis by POLH

Cite Us!