Reactome | PCNA-Dependent Long Patch Base Excision Repair

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PCNA-Dependent Long Patch Base Excision Repair Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5651798] Orlic-Milacic, Marija, 2014-11-24
dbId	5651801
displayName	PCNA-Dependent Long Patch Base Excision Repair
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 - Homo sapiens [Reaction:R-HSA-110368] POLD,POLE-mediated DNA strand displacement synthesis - Homo sapiens [Reaction:R-HSA-110363] FEN1 bound to PCNA and APEX1 cleaves flap ssDNA - Homo sapiens [Reaction:R-HSA-110371] LIG1 binds APEX1 and PCNA at SSB - Homo sapiens [Reaction:R-HSA-5651805] LIG1 bound to APEX1 and PCNA ligates SSB - Homo sapiens [Reaction:R-HSA-5651809] LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111248] Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). [LiteratureReference:5651823] Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair [LiteratureReference:111247] Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts. [LiteratureReference:111254] AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. [LiteratureReference:111256] Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA. [LiteratureReference:5651883] Mammalian base excision repair by DNA polymerases delta and epsilon [LiteratureReference:111249] Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	PCNA-Dependent Long Patch Base Excision Repair
orthologousEvent	[Pathway:R-PFA-5651801] PCNA-Dependent Long Patch Base Excision Repair - Plasmodium falciparum [Pathway:R-SPO-5651801] PCNA-Dependent Long Patch Base Excision Repair - Schizosaccharomyces pombe [Pathway:R-DDI-5651801] PCNA-Dependent Long Patch Base Excision Repair - Dictyostelium discoideum [Pathway:R-CEL-5651801] PCNA-Dependent Long Patch Base Excision Repair - Caenorhabditis elegans [Pathway:R-DME-5651801] PCNA-Dependent Long Patch Base Excision Repair - Drosophila melanogaster [Pathway:R-XTR-5651801] PCNA-Dependent Long Patch Base Excision Repair - Xenopus tropicalis [Pathway:R-SSC-5651801] PCNA-Dependent Long Patch Base Excision Repair - Sus scrofa [Pathway:R-BTA-5651801] PCNA-Dependent Long Patch Base Excision Repair - Bos taurus [Pathway:R-CFA-5651801] PCNA-Dependent Long Patch Base Excision Repair - Canis familiaris [Pathway:R-RNO-5651801] PCNA-Dependent Long Patch Base Excision Repair - Rattus norvegicus [Pathway:R-MMU-5651801] PCNA-Dependent Long Patch Base Excision Repair - Mus musculus
precedingEvent	[Reaction:R-HSA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5651801
summation	[Summation:5651935] Long-patch base excision repair (BER) can proceed through PC...

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(hasEvent)

[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway

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