Reactome | Intraflagellar transport

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Intraflagellar transport Show undefined attributes

authored	[InstanceEdit:5619483] Rothfels, Karen, 2014-08-22
created	[InstanceEdit:5620923] Rothfels, Karen, 2014-08-27
dbId	5620924
displayName	Intraflagellar transport
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5617833] Cilium Assembly - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1301080] intraciliary transport involved in cilium assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5617829] Assembly of IFT A complex - Homo sapiens [Reaction:R-HSA-5617820] Assembly of IFT B complex - Homo sapiens [Reaction:R-HSA-5617828] TRIP11:IFT20 dissociates - Homo sapiens [BlackBoxEvent:R-HSA-5617825] TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi - Homo sapiens [Reaction:R-HSA-5624951] TNPO1 binds KIF17 dimer - Homo sapiens [BlackBoxEvent:R-HSA-5624948] KIF17 enters the cilium - Homo sapiens [Reaction:R-HSA-5624949] Assembly of the anterograde IFT train - Homo sapiens [BlackBoxEvent:R-HSA-5625416] Anterograde IFT - Homo sapiens [Reaction:R-HSA-5625421] The anterograde IFT train dissociates - Homo sapiens [Reaction:R-HSA-5624952] Assembly of the retrograde IFT train - Homo sapiens [BlackBoxEvent:R-HSA-5625426] Retrograde IFT - Homo sapiens [Reaction:R-HSA-5625424] The retrograde IFT train dissociates - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5617755] SnapShot: Intraflagellar transport [LiteratureReference:5617525] Architecture and function of IFT complex proteins in ciliogenesis [LiteratureReference:5625315] Intraflagellar transport complex structure and cargo interactions [LiteratureReference:5617546] Ciliogenesis: building the cell's antenna [LiteratureReference:5609707] Cilia and Hedgehog responsiveness in the mouse [LiteratureReference:5617578] The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly [LiteratureReference:5610209] Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli [LiteratureReference:5610299] THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia [LiteratureReference:5624826] Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport [LiteratureReference:5617505] A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis [LiteratureReference:5624813] Functional coordination of intraflagellar transport motors [LiteratureReference:5617751] Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles [LiteratureReference:5618172] The roles of evolutionarily conserved functional modules in cilia-related trafficking
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Intraflagellar transport
orthologousEvent	[Pathway:R-CEL-5620924] Intraflagellar transport - Caenorhabditis elegans [Pathway:R-DME-5620924] Intraflagellar transport - Drosophila melanogaster [Pathway:R-GGA-5620924] Intraflagellar transport - Gallus gallus [Pathway:R-XTR-5620924] Intraflagellar transport - Xenopus tropicalis [Pathway:R-SSC-5620924] Intraflagellar transport - Sus scrofa [Pathway:R-BTA-5620924] Intraflagellar transport - Bos taurus [Pathway:R-CFA-5620924] Intraflagellar transport - Canis familiaris [Pathway:R-RNO-5620924] Intraflagellar transport - Rattus norvegicus [Pathway:R-MMU-5620924] Intraflagellar transport - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5620924
summation	[Summation:5625179] Intraflagellar transport (IFT) is a motor-based process that...

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(hasEvent)

[Pathway:R-HSA-5617833] Cilium Assembly

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