Reactome | Defective ACY1 does not hydrolyse mercapturic acids

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Defective ACY1 does not hydrolyse mercapturic acids Show undefined attributes

authored	[InstanceEdit:5579090] Jassal, Bijay, 2014-06-06
catalystActivity	[CatalystActivity:9638060] aminoacylase activity of ACY1 mutants:Zn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5579090] Jassal, Bijay, 2014-06-06
dbId	5579081
disease	[Disease:5579092] toxic encephalopathy
displayName	Defective ACY1 does not hydrolyse mercapturic acids
edited	[InstanceEdit:5579090] Jassal, Bijay, 2014-06-06
entityFunctionalStatus	[EntityFunctionalStatus:5579087] loss_of_function of ACY1 mutants:Zn2+ dimer [cytosol]
eventOf	[Pathway:R-HSA-5579007] Defective ACY1 causes encephalopathy - Homo sapiens
input	[DefinedSet:R-ALL-5490236] AFXBO-NAC,AFNBO-NAC [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5490294] Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family [LiteratureReference:5579051] Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism [LiteratureReference:5579107] Neurological findings in aminoacylase 1 deficiency
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective ACY1 does not hydrolyse mercapturic acids
normalReaction	[Reaction:R-HSA-5433074] ACY1:Zn2+ dimer hydrolyses mercapturic acids
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5579081
summation	[Summation:5579059] Cytosolic aminocyclases 1 and 3 (ACY1,3) can hydrolyse N-acy...
systematicName	ACY1 mutants do not hydrolyse AFXBO-NAC,AFNBO-NAC

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[Pathway:R-HSA-5579007] Defective ACY1 causes encephalopathy

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