Reactome | DKK promotes clathrin-dependent internalization of LRP6

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DKK promotes clathrin-dependent internalization of LRP6 Show undefined attributes

authored	[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:171062] early endosome membrane
created	[InstanceEdit:5368585] Rothfels, Karen, 2014-04-28
dbId	5368586
displayName	DKK promotes clathrin-dependent internalization of LRP6
edited	[InstanceEdit:5422961] Matthews, Lisa, 2014-05-07
eventOf	[Pathway:R-HSA-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists - Homo sapiens
input	[Complex:R-HSA-3769399] KRM:DKK:LRP5/6 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5368413] LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse [LiteratureReference:5368419] Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling
modified	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
name	DKK promotes clathrin-dependent internalization of LRP6
orthologousEvent	[BlackBoxEvent:R-XTR-5368586] DKK promotes clathrin-dependent internalization of LRP6 - Xenopus tropicalis [BlackBoxEvent:R-SSC-5368586] DKK promotes clathrin-dependent internalization of LRP6 - Sus scrofa [BlackBoxEvent:R-BTA-5368586] DKK promotes clathrin-dependent internalization of LRP6 - Bos taurus [BlackBoxEvent:R-RNO-5368586] DKK promotes clathrin-dependent internalization of LRP6 - Rattus norvegicus [BlackBoxEvent:R-MMU-5368586] DKK promotes clathrin-dependent internalization of LRP6 - Mus musculus
output	[Complex:R-HSA-5368514] KRM:DKK:LRP5/6 [early endosome membrane]
precedingEvent	[Reaction:R-HSA-3769401] DKK and KRM bind LRP5/6 - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5368586
summation	[Summation:5368427] Binding of DKK1 to LRP6 induces the clathrin-mediated endocy...

Referrals

(hasEvent)

[Pathway:R-HSA-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists