Reactome | APC truncation mutants are not K63 polyubiquitinated

Schema > FailedReaction > Entries

authored	[InstanceEdit:5239127] Rothfels, K, 2014-01-17
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5246695] Rothfels, K, 2014-01-22
dbId	5246696
disease	[Disease:4791250] colorectal cancer
displayName	APC truncation mutants are not K63 polyubiquitinated
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus	[EntityFunctionalStatus:5246653] loss_of_function of APC polyubiquitination mutants [cytosol]
eventOf	[Pathway:R-HSA-5467333] APC truncation mutants are not K63 polyubiquitinated - Homo sapiens
input	[DefinedSet:R-HSA-5246650] APC polyubiquitination mutants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5228658] Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the ?-catenin destruction complex
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	APC truncation mutants are not K63 polyubiquitinated
normalReaction	[Reaction:R-HSA-5246693] APC is K63-polyubiquitinated
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5246696
summation	[Summation:5246694] APC is K63 polyubiquitinated in the absence of WNT signal an...

(hasEvent)

Cite Us!