Reactome | beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]

Schema > Reaction > Entries

beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] Show undefined attributes

authored	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
catalystActivity	[CatalystActivity:70771] methylcrotonoyl-CoA carboxylase activity of 6x(Btn-MCCC1:MCCC2) [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643717] methylcrotonoyl-CoA carboxylase activity of 6x(Btn-MCCC1:MCCC2) [mitochondrial matrix] The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:508306] D'Eustachio, P, 2010-02-11
crossReference	[DatabaseIdentifier:11881080] Rhea:13591
dbId	508308
displayName	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]
eventOf	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-70772] bMC-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70761] The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency [LiteratureReference:70749] Cloning of the human MCCA and MCCB genes and mutations therein reveal the molecular cause of 3-methylcrotonyl-CoA: carboxylase deficiency
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]
orthologousEvent	[Reaction:R-BTA-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Bos taurus [Reaction:R-DDI-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Dictyostelium discoideum [Reaction:R-CEL-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Caenorhabditis elegans [Reaction:R-DME-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Drosophila melanogaster [Reaction:R-GGA-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Gallus gallus [Reaction:R-XTR-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Xenopus tropicalis [Reaction:R-SSC-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Sus scrofa [Reaction:R-CFA-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Canis familiaris [Reaction:R-RNO-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Rattus norvegicus [Reaction:R-MMU-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] - Mus musculus
output	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-70744] bMC-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29896] HCO3- [mitochondrial matrix]
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-508308
summation	[Summation:508304] Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversib...

Referrals

(hasEvent)	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism
(reverseReaction)	[Reaction:R-HSA-70773] beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]