Reactome | AP-1 stimulates IL1A transcription

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AP-1 stimulates IL1A transcription Show undefined attributes

authored	[InstanceEdit:4568741] Orlic-Milacic, M, 2013-09-16
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:4568739] Orlic-Milacic, M, 2013-09-16
dbId	4568740
displayName	AP-1 stimulates IL1A transcription
edited	[InstanceEdit:4568741] Orlic-Milacic, M, 2013-09-16
eventOf	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-4568733] IL1A gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4569005] Serotonin-inducible transcription of interleukin-1alpha in uterine smooth muscle cells requires an AP-1 site: cloning and partial characterization of the rat IL-1alpha promoter [LiteratureReference:4568991] A polymorphism in the upstream regulatory region of the interleukin-1? gene confers differential binding by transcription factors of the AP-1 family [LiteratureReference:4568976] An AP-1 site is involved in the NGF induction of IL-1 alpha in PC12 cells [LiteratureReference:4569000] Dermatotoxic chemical stimulate of c-jun and c-fos transcription and AP-1 DNA binding in human keratinocytes [LiteratureReference:4568998] The transcription factor AP-1 binds to the human interleukin 1 alpha promoter [LiteratureReference:4568985] N-myc Downstream-regulated Gene 1 Promotes Tumor Inflammatory Angiogenesis through JNK Activation and Autocrine Loop of Interleukin-1? by Human Gastric Cancer Cells [LiteratureReference:4569007] Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AP-1 stimulates IL1A transcription
output	[EntityWithAccessionedSequence:R-HSA-445746] Myr82K-Myr83K-IL1A [extracellular region]
precedingEvent	[Reaction:R-HSA-4568737] AP-1 transcription factor binds IL1A promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-4568736] Positive gene expression regulation by 'p-2S-JUN:p-2S,2T-FOS:IL1A gene [nucleoplasm]'
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-4568740
summation	[Summation:4569016] The AP-1 complex (FOS:JUN) binds IL1A promoter and stimulate...

Referrals

(hasEvent)

[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)