Reactome | FAR1 reduces PalmCoA to HXOL

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FAR1 reduces PalmCoA to HXOL Show undefined attributes

authored	[InstanceEdit:398115] D'Eustachio, P, 2009-03-16 18:50:14
catalystActivity	[CatalystActivity:390410] oxidoreductase activity of FAR1 [peroxisomal membrane]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:390413] D'Eustachio, P, 2009-02-06 21:28:38
crossReference	[DatabaseIdentifier:11880390] Rhea:36316
dbId	390425
displayName	FAR1 reduces PalmCoA to HXOL
edited	[InstanceEdit:398202] D'Eustachio, P, 2009-03-18 13:33:40
eventOf	[Pathway:R-HSA-9640463] Wax biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8848586] Transport of cytosolic HXOL to the peroxisome - Homo sapiens [Reaction:R-HSA-382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix - Homo sapiens
input	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:390429] Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	FAR1 reduces PalmCoA to HXOL palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1]
orthologousEvent	[Reaction:R-DDI-390425] FAR1 reduces PalmCoA to HXOL - Dictyostelium discoideum [Reaction:R-CEL-390425] FAR1 reduces PalmCoA to HXOL - Caenorhabditis elegans [Reaction:R-DME-390425] FAR1 reduces PalmCoA to HXOL - Drosophila melanogaster [Reaction:R-GGA-390425] FAR1 reduces PalmCoA to HXOL - Gallus gallus [Reaction:R-SSC-390425] FAR1 reduces PalmCoA to HXOL - Sus scrofa [Reaction:R-BTA-390425] FAR1 reduces PalmCoA to HXOL - Bos taurus [Reaction:R-CFA-390425] FAR1 reduces PalmCoA to HXOL - Canis familiaris [Reaction:R-RNO-390425] FAR1 reduces PalmCoA to HXOL - Rattus norvegicus [Reaction:R-MMU-390425] FAR1 reduces PalmCoA to HXOL - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-8848577] HXOL [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-390425
summation	[Summation:390417] Peroxisomal fatty acyl-CoA reductase 1 (FAR1) catalyzes the ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-8848586] Transport of cytosolic HXOL to the peroxisome [Reaction:R-HSA-382575] ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix
(hasEvent)	[Pathway:R-HSA-9640463] Wax biosynthesis