Reactome | DBC1 is phosphorylated by ATM/ART

Schema > Reaction > Entries

authored	[InstanceEdit:4793943] Shamovsky, V, 2013-10-28
catalystActivity	[CatalystActivity:421861] protein serine/threonine kinase activity of ATM/ATR kinase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId	3371567
displayName	DBC1 is phosphorylated by ATM/ART
edited	[InstanceEdit:5324627] Shamovsky, V, 2014-02-17
eventOf	[Pathway:R-HSA-3371453] Regulation of HSF1-mediated heat shock response - Homo sapiens
followingEvent	[Reaction:R-HSA-3371537] DBC1 binds SIRT1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3371479] DBC1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3371587] DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage [LiteratureReference:3371487] Regulation of SIRT1 activity by genotoxic stress
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DBC1 is phosphorylated by ATM/ART
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3371569] p-T454-DBC1 [nucleoplasm]
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5324628] Pani, Bibhusita, 2014-02-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3371567
summation	[Summation:5096417] The stress-induced DBC1-SIRT1 interaction required the ATM/A...

(hasEvent)	[Pathway:R-HSA-3371453] Regulation of HSF1-mediated heat shock response
(precedingEvent)	[Reaction:R-HSA-3371537] DBC1 binds SIRT1

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