Reactome | Formation of PRC2-EZH2 complex

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Formation of PRC2-EZH2 complex Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3240958] Orlic-Milacic, M, 2013-03-27
dbId	3240957
displayName	Formation of PRC2-EZH2 complex
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3240295] PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-212278] EED [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212298] EZH2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212223] RBBP4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212227] RBBP7 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212217] SUZ12 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:212244] Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	Formation of PRC2-EZH2 complex
orthologousEvent	[Reaction:R-DME-3240957] Formation of PRC2-EZH2 complex - Drosophila melanogaster [Reaction:R-XTR-3240957] Formation of PRC2-EZH2 complex - Xenopus tropicalis [Reaction:R-DRE-3240957] Formation of PRC2-EZH2 complex - Danio rerio [Reaction:R-SSC-3240957] Formation of PRC2-EZH2 complex - Sus scrofa [Reaction:R-BTA-3240957] Formation of PRC2-EZH2 complex - Bos taurus [Reaction:R-RNO-3240957] Formation of PRC2-EZH2 complex - Rattus norvegicus [Reaction:R-MMU-3240957] Formation of PRC2-EZH2 complex - Mus musculus
output	[Complex:R-HSA-212285] PRC2 (EZH2) Core [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-3240782] E2F1/2/3 stimulates EED transcription - Homo sapiens [BlackBoxEvent:R-HSA-3240783] E2F1/2/3 stimulates EZH2 transcription - Homo sapiens [BlackBoxEvent:R-HSA-3240787] E2F1/2/3 stimulates SUZ12 transcription - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3240957
summation	[Summation:3779421] The Polycomb repressor complex 2, PRC2-EZH2, consists of 5 p...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3240295] PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter