Reactome | E2F1/2/3 stimulates EZH2 transcription

Schema > BlackBoxEvent > Entries

E2F1/2/3 stimulates EZH2 transcription Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3240784] Orlic-Milacic, M, 2013-03-27
dbId	3240783
displayName	E2F1/2/3 stimulates EZH2 transcription
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3240957] Formation of PRC2-EZH2 complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3240762] EZH2 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3240776] EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1/2/3 stimulates EZH2 transcription
output	[EntityWithAccessionedSequence:R-HSA-212298] EZH2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3240777] E2F1/2/3:DP1/2 binds EZH2 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-3240786] Positive gene expression regulation by 'EZH2 Gene:E2F1/2/3:DP1/2 [nucleoplasm]'
regulationReference	[RegulationReference:9641486] Positive gene expression regulation by 'EZH2 Gene:E2F1/2/3:DP1/2 [nucleoplasm]' EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3240783
summation	[Summation:3777184] In growing cells, the transcription of EZH2 methyltransferas...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3240957] Formation of PRC2-EZH2 complex

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