Reactome | USP7 deubiquitinates MDM2

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USP7 deubiquitinates MDM2 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:3215307] cysteine-type deubiquitinase activity of DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3215285] Orlic-Milacic, M, 2013-03-15
dbId	3215295
displayName	USP7 deubiquitinates MDM2
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
input	[Complex:R-HSA-3222079] DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3222085] Critical role for Daxx in regulating Mdm2 [LiteratureReference:3215284] A dynamic role of HAUSP in the p53-Mdm2 pathway [LiteratureReference:3215305] Molecular recognition of p53 and MDM2 by USP7/HAUSP [LiteratureReference:3215308] Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway [LiteratureReference:5689959] Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 [LiteratureReference:6805031] Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	USP7 deubiquitinates MDM2
orthologousEvent	[Reaction:R-SSC-3215295] USP7 deubiquitinates MDM2 - Sus scrofa [Reaction:R-BTA-3215295] USP7 deubiquitinates MDM2 - Bos taurus [Reaction:R-CFA-3215295] USP7 deubiquitinates MDM2 - Canis familiaris [Reaction:R-RNO-3215295] USP7 deubiquitinates MDM2 - Rattus norvegicus [Reaction:R-MMU-3215295] USP7 deubiquitinates MDM2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3222068] DAXX [nucleoplasm] [CandidateSet:R-HSA-6805030] p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] 2 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3215278] USP7 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3215295
summation	[Summation:5633482] In the presence of DAXX, USP7 deubiquitinates MDM2. DAXX exp...

Referrals

(hasEvent)

[Pathway:R-HSA-6804757] Regulation of TP53 Degradation