Reactome | Activated ERKs phosphorylate ERF

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Activated ERKs phosphorylate ERF Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3209170] Orlic-Milacic, M, 2013-03-01
dbId	3209160
displayName	Activated ERKs phosphorylate ERF
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-3209159] Phosphorylated ERF translocates to the cytosol - Homo sapiens
inferredFrom	[Reaction:R-NUL-3245934] Mapk1 (Erk2) phosphorylates ERF - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2534321] ERF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:3209175] ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation [LiteratureReference:3209161] ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated ERKs phosphorylate ERF
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3209166] p-T526-ERF [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3209160
summation	[Summation:3245928] Activated ERKs (ERK1 i.e. MAPK3 and ERK2 i.e. MAPK1) phospho...

Referrals

(hasEvent)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence
(precedingEvent)	[Reaction:R-HSA-3209159] Phosphorylated ERF translocates to the cytosol
(inferredTo)	[Reaction:R-NUL-3245934] Mapk1 (Erk2) phosphorylates ERF