Reactome | GSK3B [cytosol]

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GSK3B [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:208885] protein serine/threonine kinase activity of GSK3B [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1226052] FRAT1,2:GSK3beta [cytosol] - Homo sapiens [Complex:R-HSA-196222] p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] - Homo sapiens [Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9687724] GSK3B binds GSKi - Homo sapiens [Reaction:R-HSA-5323526] FRAT proteins bind GSK3beta - Homo sapiens [FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex - Homo sapiens [FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex - Homo sapiens [FailedReaction:R-HSA-4791278] APC truncation mutants have impaired AXIN binding - Homo sapiens [Reaction:R-HSA-195251] Assembly of the destruction complex - Homo sapiens
created	[InstanceEdit:2997550] Jupe, S, 2013-01-23
dbId	2997551
displayName	GSK3B [cytosol]
endCoordinate	420
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-2997551] GSK3B [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-198619] Glycogen synthase kinase-3 beta [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-2997551] GSK3B [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-2997551] GSK3B [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-2997551] GSK3B [cytosol] - Sus scrofa [GenomeEncodedEntity:R-DRE-2997551] Ghost homologue of GSK3B [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-GGA-2997551] GSK3B [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-2997551] GSK3B [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-2997551-2] GSK3B [cytosol] - Drosophila melanogaster [DefinedSet:R-DME-2997551-3] Homologues of GSK3B [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-2997551] GSK3B [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-2997551-2] GSK3B [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-2997551-3] GSK3B [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-2997551-4] Homologues of GSK3B [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-2997551] GSK3B [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-2997551] GSK3B [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SPO-2997551-2] GSK3B [cytosol] - Schizosaccharomyces pombe [DefinedSet:R-SPO-2997551-3] Homologues of GSK3B [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-2997551] GSK3B [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-2997551-2] GSK3B [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-2997551-3] GSK3B [cytosol] - Saccharomyces cerevisiae [DefinedSet:R-SCE-2997551-4] Homologues of GSK3B [cytosol] - Saccharomyces cerevisiae
memberOf	[DefinedSet:R-HSA-198358] GSK3 [cytosol] - Homo sapiens
modified	[InstanceEdit:3448660] Wu, G, 2013-05-16
name	GSK3B Glycogen synthase kinase-3 beta GSK3B_HUMAN
referenceEntity	[ReferenceGeneProduct:404223] UniProt:P49841 GSK3B
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2997551
startCoordinate	1

Referrals

(input)	[FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex [FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex [FailedReaction:R-HSA-4791278] APC truncation mutants have impaired AXIN binding [Reaction:R-HSA-9687724] GSK3B binds GSKi [Reaction:R-HSA-195251] Assembly of the destruction complex [Reaction:R-HSA-5323526] FRAT proteins bind GSK3beta
(physicalEntity)	[CatalystActivity:208885] protein serine/threonine kinase activity of GSK3B [cytosol]
(hasComponent)	[Complex:R-HSA-196222] p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Complex:R-HSA-195322] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Complex:R-HSA-1226052] FRAT1,2:GSK3beta [cytosol] [Complex:R-HSA-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Complex:R-HSA-1504204] GSK3B:AXIN1 [cytosol] [Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Complex:R-HSA-9687663] GSK3B:GSKi [cytosol]
(activeUnit)	[CatalystActivity:196226] protein serine/threonine kinase activity of p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [CatalystActivity:196225] protein serine/threonine kinase activity of p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [CatalystActivity:196224] protein serine/threonine kinase activity of p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [CatalystActivity:1505507] protein serine/threonine kinase activity of WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-195284] CK1alpha (GSK3) [cytosol]
(hasMember)	[DefinedSet:R-HSA-198358] GSK3 [cytosol]

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