Reactome | ABCG5:ABCG8 transports sterols from cytosol to extracellular region

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ABCG5:ABCG8 transports sterols from cytosol to extracellular region Show undefined attributes

authored	[InstanceEdit:349660] D'Eustachio, P, 2008-05-12 17:46:52
catalystActivity	[CatalystActivity:265785] sterol transporter activity of ABCG5:ABCG8 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:265780] D'Eustachio, P, 2008-04-21 13:25:07
dbId	265783
displayName	ABCG5:ABCG8 transports sterols from cytosol to extracellular region
edited	[InstanceEdit:353690] D'Eustachio, P, 2008-06-13 14:03:50
eventOf	[Pathway:R-HSA-1369062] ABC transporters in lipid homeostasis - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-265784] sterols [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:265544] Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	ABCG5:ABCG8 transports sterols from cytosol to extracellular region ABCG5:ABCG8-mediated export of cholesterol and phytosterols sterols[cytosol] + ATP => sterols[extracellular] + ADP + Pi
orthologousEvent	[Reaction:R-PFA-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Plasmodium falciparum [Reaction:R-SCE-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Saccharomyces cerevisiae [Reaction:R-DDI-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Dictyostelium discoideum [Reaction:R-CEL-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Caenorhabditis elegans [Reaction:R-DME-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Drosophila melanogaster [Reaction:R-GGA-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Gallus gallus [Reaction:R-SSC-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Sus scrofa [Reaction:R-BTA-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Bos taurus [Reaction:R-CFA-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Canis familiaris [Reaction:R-RNO-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Rattus norvegicus [Reaction:R-MMU-265783] ABCG5:ABCG8 transports sterols from cytosol to extracellular region - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-ALL-265781] sterols [extracellular region]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:353689] Jassal, Bijay, 2008-06-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-265783
summation	[Summation:265782] The complex of ATP-binding cassette sub-family G members 5 a...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5679145] Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region [FailedReaction:R-HSA-5679101] Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-1369062] ABC transporters in lipid homeostasis