Reactome | 4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold

Schema > BlackBoxEvent > Entries

4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold Show undefined attributes

authored	[InstanceEdit:2564829] Lill, Roland, 2012-11-07
catalystActivity	[CatalystActivity:2564821] electron transfer activity of NDOR1:CIAPIN1 reduced [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2564823] May, B, 2012-11-07
dbId	2564826
displayName	4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold
edited	[InstanceEdit:2564820] May, B, 2012-11-07
eventOf	[Pathway:R-HSA-2564830] Cytosolic iron-sulfur cluster assembly - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2564828] CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins - Homo sapiens
inferredFrom	[BlackBoxEvent:R-SCE-2564822] 4Fe-4S cluster assembles on CFD1:NBP35 scaffold - Saccharomyces cerevisiae
input	4 × [SimpleEntity:R-ALL-71160] Fe [cytosol] 2 × [Complex:R-HSA-2564799] NUBP1:4Fe-4S [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-2564767] NUBP2 [cytosol] 4 × [SimpleEntity:R-ALL-2566513] S [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2564731] Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold
output	[Complex:R-HSA-2564798] NUBP2:4Fe-4S:NUBP1 [cytosol]
precedingEvent	[Reaction:R-HSA-2564824] NADPH reduces NDOR1:CIAPIN1 - Homo sapiens
regulatedBy	[Requirement:R-HSA-8952939] Requirement by 'ABC7 dimer [mitochondrial inner membrane]'
regulationReference	[RegulationReference:9641443] Requirement by 'ABC7 dimer [mitochondrial inner membrane]' Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3018411] Uringa, Evert-Jan, 2013-02-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2564826
summation	[Summation:2564703] A [4Fe-4S] cluster is assembled on a scaffold composed of th... [Summation:8952946] Mitochondria export via a mitochondrial ABC transporter (yea...

Referrals

(hasEvent)	[Pathway:R-HSA-2564830] Cytosolic iron-sulfur cluster assembly
(precedingEvent)	[BlackBoxEvent:R-HSA-2564828] CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins
(inferredTo)	[BlackBoxEvent:R-SCE-2564822] 4Fe-4S cluster assembles on CFD1:NBP35 scaffold

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