Reactome | tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

Schema > Reaction > Entries

tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer Show undefined attributes

authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359096] selenocysteine-tRNA ligase activity of SARS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
dbId	2408526
displayName	tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
eventOf	[Pathway:R-HSA-2408557] Selenocysteine synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2408507] Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-200736] L-Ser [cytosol] [GenomeEncodedEntity:R-HSA-5357732] tRNA(Sec) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380058] Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase [LiteratureReference:5359382] Selenocysteine synthesis in mammalia: an identity switch from tRNA(Ser) to tRNA(Sec) [LiteratureReference:5359369] Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [GenomeEncodedEntity:R-HSA-5357730] Ser-tRNA(Sec) [cytosol]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2408526
summation	[Summation:5359374] The synthetic cycle of selenocysteine (Sec) synthesis starts...

Referrals

(hasEvent)	[Pathway:R-HSA-2408557] Selenocysteine synthesis
(precedingEvent)	[Reaction:R-HSA-2408507] Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK

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