Reactome | p-6Y-FGFR3 K650M [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-6Y-FGFR3 K650M [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2033334] Activated FGFR3 K650M mutant [plasma membrane] - Homo sapiens
created	[InstanceEdit:2032958] Rothfels, K, 2012-01-08
crossReference	[DatabaseIdentifier:2032956] COSMIC:COSV53391370 [DatabaseIdentifier:2032957] COSMIC:COSM85791
dbId	2032959
disease	[Disease:1493885] bladder carcinoma [Disease:2032940] bone development disease [Disease:1500689] cancer [Disease:1614388] multiple myeloma [Disease:1625209] thanatophoric dysplasia
displayName	p-6Y-FGFR3 K650M [plasma membrane]
endCoordinate	806
hasModifiedResidue	[ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ReplacedResidue:1614403] L-lysine 650 replaced with L-methionine
inDisease	true
inferredTo	[EntityWithAccessionedSequence:R-HSA-2033300] p-8Y-FGFR2 K660M [plasma membrane] - Homo sapiens
literatureReference	[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype [LiteratureReference:1637853] Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders
modified	[InstanceEdit:5649596] Rothfels, Karen, 2014-11-20
name	p-6Y-FGFR3 K650M
referenceEntity	[ReferenceGeneProduct:403340] UniProt:P22607 FGFR3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2032959
startCoordinate	23

Referrals

(hasComponent)

[Complex:R-HSA-2033334] Activated FGFR3 K650M mutant [plasma membrane]