Reactome | Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)

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Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) Show undefined attributes

authored	[InstanceEdit:203275] Ouwehand, W.H., 2007-11-12 16:45:54
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:202725] de Bono, B, 2007-11-11 16:10:42
dbId	202718
displayName	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)
eventOf	[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens [Pathway:R-HSA-216083] Integrin cell surface interactions - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197845] F11R [plasma membrane] [Complex:R-HSA-198196] Integrin alphaLbeta2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202753] The role of junctional adhesion molecules in vascular inflammation [LiteratureReference:203358] Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A [LiteratureReference:203343] The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain [LiteratureReference:203339] JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)
orthologousEvent	[Reaction:R-SSC-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Sus scrofa [Reaction:R-BTA-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Bos taurus [Reaction:R-CFA-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Canis familiaris [Reaction:R-RNO-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Rattus norvegicus [Reaction:R-MMU-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Mus musculus
output	[Complex:R-HSA-202749] Integrin alphaLbeta2:F11R [plasma membrane]
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203274] Zwaginga, JJ, 2007-11-12 16:47:00
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202718
summation	[Summation:203342] JAM-A plays a key role in leukocyte transmigration and infla...

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