Reactome | EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue

Schema > Reaction > Entries

EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue Show undefined attributes

authored	[InstanceEdit:2022912] Jassal, B, 2011-12-01
catalystActivity	[CatalystActivity:2022845] glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity of EXT1:EXT2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2022912] Jassal, B, 2011-12-01
dbId	2022919
displayName	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue
edited	[InstanceEdit:2022912] Jassal, B, 2011-12-01
eventOf	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2022856] EXT1:EXT2 transfers GlcNAc to heparan - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:19672] heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
input	[DefinedSet:R-HSA-2076551] GlcA-Gal-Gal-Xyl-HS proteins [Golgi lumen] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2022914] The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate [LiteratureReference:2022877] Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes [LiteratureReference:2022859] Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue The addition of GlcNAc to the terminal glucuronate residue starts heparan polymerization
orthologousEvent	[Reaction:R-DME-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Drosophila melanogaster [Reaction:R-DRE-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Danio rerio [Reaction:R-SSC-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Sus scrofa [Reaction:R-BTA-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Bos taurus [Reaction:R-CFA-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Canis familiaris [Reaction:R-RNO-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Rattus norvegicus [Reaction:R-MMU-2022919] EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue - Mus musculus
output	[DefinedSet:R-HSA-2076465] Heparan-PGs [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Homo sapiens [Reaction:R-HSA-744231] SLC35D2 exchanges UDP-GlcNAc for UMP - Homo sapiens [Reaction:R-HSA-741450] SLC35A3 exchanges UDP-GlcNAc for UMP - Homo sapiens [Reaction:R-HSA-742354] SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2022919
summation	[Summation:2022898] Exostosin1 and 2 (EXT1 and 2) are dual specificity enzymes w...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9036290] Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan [FailedReaction:R-HSA-9036283] Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue
(hasEvent)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-HSA-2022856] EXT1:EXT2 transfers GlcNAc to heparan