Reactome | p-8Y-FGFR1c P252T [plasma membrane]

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p-8Y-FGFR1c P252T [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2018773] p-8Y-FGFR1c P252T dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:2011869] Rothfels, K, 2011-11-22
dbId	2011868
disease	[Disease:1500699] lung cancer
displayName	p-8Y-FGFR1c P252T [plasma membrane]
endCoordinate	822
hasModifiedResidue	[ReplacedResidue:1614384] L-proline 252 replaced with L-threonine [ModifiedResidue:2011867] O4'-phospho-L-tyrosine at 463 [ModifiedResidue:2011863] O4'-phospho-L-tyrosine at 583 [ModifiedResidue:2011864] O4'-phospho-L-tyrosine at 585 [ModifiedResidue:2011862] O4'-phospho-L-tyrosine at 653 [ModifiedResidue:2011865] O4'-phospho-L-tyrosine at 654 [ModifiedResidue:2011860] O4'-phospho-L-tyrosine at 730 [ModifiedResidue:1838976] O4'-phospho-L-tyrosine at 766 [ModifiedResidue:2011859] O4'-phospho-L-tyrosine at 776
inDisease	true
inferredFrom	[EntityWithAccessionedSequence:R-HSA-2011858] p-8Y-FGFR1c P252R [plasma membrane] - Homo sapiens
literatureReference	[LiteratureReference:1614272] Somatic mutations of the protein kinase gene family in human lung cancer [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
modified	[InstanceEdit:9036004] Rothfels, Karen, 2018-01-26
name	p-8Y-FGFR1c P252T
referenceEntity	[ReferenceIsoform:54814] UniProt:P11362-1 FGFR1
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2011868
startCoordinate	22
summation	[Summation:1614382] thought to increase # hydrogen bonds, increase ligand affini...

Referrals

(hasComponent)	[Complex:R-HSA-2018773] p-8Y-FGFR1c P252T dimer [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-2011858] p-8Y-FGFR1c P252R [plasma membrane]