Reactome | COASY phosphorylates DP-CoA

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COASY phosphorylates DP-CoA Show undefined attributes

authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:196818] dephospho-CoA kinase activity of COASY [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
crossReference	[DatabaseIdentifier:11880756] Rhea:18246
dbId	196773
displayName	COASY phosphorylates DP-CoA
eventOf	[Pathway:R-HSA-196783] Coenzyme A biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9837333] SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP - Homo sapiens [Reaction:R-HSA-199216] SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-199202] Phosphopantetheine conjugation of the ACP domain of FAS - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-196778] DP-CoA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196745] Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase) [LiteratureReference:196824] Subcellular localization and regulation of coenzyme A synthase
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	COASY phosphorylates DP-CoA 3'-dephospho-CoA + ATP => ADP + CoA + H(+) Phosphorylation of dephospho-CoA to produce CoA
orthologousEvent	[Reaction:R-SCE-196773] COASY phosphorylates DP-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-196773] COASY phosphorylates DP-CoA - Schizosaccharomyces pombe [Reaction:R-DDI-196773] COASY phosphorylates DP-CoA - Dictyostelium discoideum [Reaction:R-CEL-196773] COASY phosphorylates DP-CoA - Caenorhabditis elegans [Reaction:R-GGA-196773] COASY phosphorylates DP-CoA - Gallus gallus [Reaction:R-XTR-196773] COASY phosphorylates DP-CoA - Xenopus tropicalis [Reaction:R-DRE-196773] COASY phosphorylates DP-CoA - Danio rerio [Reaction:R-SSC-196773] COASY phosphorylates DP-CoA - Sus scrofa [Reaction:R-BTA-196773] COASY phosphorylates DP-CoA - Bos taurus [Reaction:R-CFA-196773] COASY phosphorylates DP-CoA - Canis familiaris [Reaction:R-RNO-196773] COASY phosphorylates DP-CoA - Rattus norvegicus [Reaction:R-MMU-196773] COASY phosphorylates DP-CoA - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-196754] COASY transfers an adenylyl group from ATP to PPANT - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9840788] Hill, David P, 2023-07-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-196773
summation	[Summation:196792] The kinase activity of CoA synthase (COASY) catalyzes the ph...

Referrals

(hasEvent)	[Pathway:R-HSA-196783] Coenzyme A biosynthesis
(precedingEvent)	[Reaction:R-HSA-9837333] SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP [Reaction:R-HSA-199216] SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix [Reaction:R-HSA-199202] Phosphopantetheine conjugation of the ACP domain of FAS