Reactome | Proteosome-mediated degradation of APOBEC3G

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Proteosome-mediated degradation of APOBEC3G Show undefined attributes

authored	[InstanceEdit:180020] Matthews, L, 2006-05-15 23:53:25
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:180586] Matthews, L, 2006-05-23 13:59:44
dbId	180603
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Proteosome-mediated degradation of APOBEC3G
edited	[InstanceEdit:192229] Matthews, L, 2007-01-30 11:27:41
eventOf	[Pathway:R-HSA-180585] Vif-mediated degradation of APOBEC3G - Homo sapiens
input	[Complex:R-HSA-180577] multi-ubiquitinated APOBEC3G:Vif:Cul5:SCF complex [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:180580] Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex [LiteratureReference:180754] The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif [LiteratureReference:180741] Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proteosome-mediated degradation of APOBEC3G
output	3 × [DefinedSet:R-HSA-113595] Ub [cytosol] [Complex:R-HSA-180539] Vif:Cul5:SCF complex [cytosol]
precedingEvent	[Reaction:R-HSA-180540] Multi-ubiquitination of APOBEC3G - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192288] Mulder, L, 2007-01-30 22:57:00 [InstanceEdit:192290] Simon, V, 2007-01-30 23:07:12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-180603
summation	[Summation:180748] Following multi-ubiquitination by the Vif-Cul5-SCF complex, ...

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[Pathway:R-HSA-180585] Vif-mediated degradation of APOBEC3G

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