Reactome | EGFR [plasma membrane]

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EGFR [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-445016] L1-EGFR trans-heterodimer [plasma membrane] - Homo sapiens [Complex:R-HSA-8857547] HBEGF:EGFR [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-445069] L1-EGFR trans-heterodimerization - Homo sapiens [Reaction:R-HSA-1248677] Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody - Homo sapiens [Reaction:R-HSA-9851407] FAM83B, (FAM83A, FAM83D) bind EGFR - Homo sapiens [Reaction:R-HSA-177942] EGFR binds EGF ligand - Homo sapiens [Reaction:R-HSA-9674531] AAMP binds EGFR - Homo sapiens [BlackBoxEvent:R-HSA-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor - Homo sapiens
created	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
dbId	179837
displayName	EGFR [plasma membrane]
endCoordinate	1210
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-179837] EGFR [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-RNO-179837] EGFR [plasma membrane] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-179837] EGFR [plasma membrane] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-179837] EGFR [plasma membrane] - Bos taurus [EntityWithAccessionedSequence:R-SSC-179837] EGFR [plasma membrane] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-179837] EGFR [plasma membrane] - Danio rerio [EntityWithAccessionedSequence:R-XTR-179837] EGFR [plasma membrane] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-179837] EGFR [plasma membrane] - Gallus gallus [EntityWithAccessionedSequence:R-DME-179837] EGFR [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-179837] EGFR [plasma membrane] - Caenorhabditis elegans
memberOf	[DefinedSet:R-HSA-9610864] HCMV Host Cell Receptors [plasma membrane] - Homo sapiens
name	EGFR Epidermal Growth Factor Receptor
producedByEvent	[BlackBoxEvent:R-HSA-8874797] EGFR gene expression is stimulated by TFAP2C - Homo sapiens
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-179837
startCoordinate	25

Referrals

(hasComponent)	[Complex:R-HSA-1248675] EGFR:Cetuximab [plasma membrane] [Complex:R-HSA-445016] L1-EGFR trans-heterodimer [plasma membrane] [Complex:R-HSA-8857547] HBEGF:EGFR [plasma membrane] [Complex:R-HSA-179847] EGF:EGFR [plasma membrane] [Complex:R-HSA-9851427] EGFR:FAM83B,(FAM83A, FAM83D) [plasma membrane] [Complex:R-HSA-9674862] EGFR:AAMP [plasma membrane] [Complex:R-HSA-9624419] EGFR:EGF-like ligands [plasma membrane]
(input)	[Reaction:R-HSA-1248677] Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody [Reaction:R-HSA-445069] L1-EGFR trans-heterodimerization [Reaction:R-HSA-9851407] FAM83B, (FAM83A, FAM83D) bind EGFR [Reaction:R-HSA-9674531] AAMP binds EGFR [BlackBoxEvent:R-HSA-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor [Reaction:R-HSA-177942] EGFR binds EGF ligand
(normalEntity)	[EntityFunctionalStatus:5638136] loss_of_function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane] [EntityFunctionalStatus:5637721] gain_of_function of Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-9837684] (EGFR,IGF1R) [plasma membrane]
(requiredInputComponent)	[CellDevelopmentStep:R-HSA-9725621] Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis
(entityOnOtherCell)	[Complex:R-HSA-445016] L1-EGFR trans-heterodimer [plasma membrane] [Reaction:R-HSA-445069] L1-EGFR trans-heterodimerization
(output)	[BlackBoxEvent:R-HSA-8874797] EGFR gene expression is stimulated by TFAP2C
(hasMember)	[DefinedSet:R-HSA-9610864] HCMV Host Cell Receptors [plasma membrane]
(activeUnit)	[CatalystActivity:183047] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [CatalystActivity:182979] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] [CatalystActivity:8867039] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [CatalystActivity:9624433] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] [CatalystActivity:9624430] protein tyrosine kinase activity of EGF-like ligands:EGFR dimer [plasma membrane]

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