Reactome | Interactions of Vpr with host cellular proteins

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Interactions of Vpr with host cellular proteins Show undefined attributes

authored	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
created	[InstanceEdit:176035] Gopinathrao, G, 2006-02-28 21:06:02
dbId	176033
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Interactions of Vpr with host cellular proteins
edited	[InstanceEdit:180608] Matthews, L, 2006-05-15 07:16:46
eventOf	[Pathway:R-HSA-162909] Host Interactions of HIV factors - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-180897] Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization - Homo sapiens [Pathway:R-HSA-180910] Vpr-mediated nuclear import of PICs - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182325] Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint [LiteratureReference:182317] Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular function of fission yeast Schizosaccharomyces pombe [LiteratureReference:182356] Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr [LiteratureReference:182330] HIV-1 VPR modulates cell cycle G2/M transition through an alternative cellular mechanism other than the classic mitotic checkpoints [LiteratureReference:182331] HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 [LiteratureReference:182352] HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection [LiteratureReference:182328] HIV-1 viral protein R (Vpr) & host cellular responses [LiteratureReference:182340] Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B [LiteratureReference:182318] Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest [LiteratureReference:182337] Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity [LiteratureReference:180703] Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions [LiteratureReference:180857] The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore [LiteratureReference:182333] The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells [LiteratureReference:182336] Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Interactions of Vpr with host cellular proteins
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:182675] Zhao, RY, 2006-07-11 22:08:52
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-176033
summation	[Summation:180936] Vpr has been implicated in multiple processes during HIV-1 r...

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[Pathway:R-HSA-162909] Host Interactions of HIV factors

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