Reactome | RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers

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RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:182891] RNA-DNA hybrid ribonuclease activity of RTC with extending second-strand DNA [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:173765] Gopinathrao, G, 2006-02-16 23:18:33
dbId	173769
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-164525] Plus-strand DNA synthesis - Homo sapiens
figure	[Figure:180426] /figures/RT_event6.jpg
followingEvent	[Reaction:R-HSA-164512] Second strand transfer by annealing complementary PBS sequences - Homo sapiens
input	[Complex:R-HSA-182880] RTC with extending second-strand DNA [cytosol]
isInDisease	true
isInferred	false
literatureReference	[Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM [LiteratureReference:177456] Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase [LiteratureReference:175646] The HIV-1 reverse transcription (RT) process as target for RT inhibitors
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
output	[Complex:R-HSA-173824] RTC without viral RNA template [cytosol]
precedingEvent	[Reaction:R-HSA-164513] 3' PPT-primed initiation of plus-strand DNA synthesis - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-173769
summation	[Summation:177430] RNase H catalyzes the precise cleavage of the bonds linking ...

Referrals

(hasEvent)	[Pathway:R-HSA-164525] Plus-strand DNA synthesis
(precedingEvent)	[Reaction:R-HSA-164512] Second strand transfer by annealing complementary PBS sequences

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