Reactome | NS1 binds PKR

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NS1 binds PKR Show undefined attributes

authored	[InstanceEdit:5146782] Gillespie, ME, 2013-11-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168887] 2007-04-16 22:35:07
dbId	168896
disease	[Disease:1660558] influenza
displayName	NS1 binds PKR
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-169131] Inhibition of PKR - Homo sapiens [Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6537] mitigation of host antiviral defense response
input	[EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] [Complex:R-FLU-169143] NS1 dimer [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9835909] Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase [LiteratureReference:3196043] Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication [LiteratureReference:9835877] Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells [LiteratureReference:9835961] Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon [LiteratureReference:9835960] Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR [LiteratureReference:9841977] Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA
modified	[InstanceEdit:9841997] Stephan, Ralf, 2023-08-16
name	NS1 binds PKR
output	[Complex:R-HSA-169142] NS1 Homodimer:PKR Complex [cytosol]
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:170177] Gale M, Jr, 2004-05-12 19:00:00
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168896
summation	[Summation:178516] Influenza virus inhibits the host double-stranded-RNA-activa...

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