Reactome | Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)

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Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) Show undefined attributes

authored	[InstanceEdit:5146782] Gillespie, ME, 2013-11-18
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:168887] 2007-04-16 22:35:07
dbId	168859
disease	[Disease:1660558] influenza
displayName	Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)
eventOf	[Pathway:R-HSA-168315] Inhibition of Host mRNA Processing and RNA Silencing - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2132823] suppression by virus of host mRNA processing
input	[EntityWithAccessionedSequence:R-HSA-169104] CPSF4 [nucleoplasm] [Complex:R-FLU-169145] NS1 Homodimer [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:169071] The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo [LiteratureReference:169092] Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs [LiteratureReference:169064] Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS [LiteratureReference:169112] Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site
modified	[InstanceEdit:9863157] D'Eustachio, Peter, 2024-02-27
name	Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)
output	[Complex:R-HSA-169074] CPSF:NS1 Complex [nucleoplasm]
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:170177] Gale M, Jr, 2004-05-12 19:00:00
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168859
summation	[Summation:169095] Influenza virus's non-structural protein (NS1) binds to the ...

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(hasEvent)

[Pathway:R-HSA-168315] Inhibition of Host mRNA Processing and RNA Silencing

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