Reactome | Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex

Schema > Reaction > Entries

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:167635] Gillespie, ME, 2005-10-20 20:40:48
dbId	167637
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex
eventOf	[Pathway:R-HSA-164939] Nef mediated downregulation of CD28 cell surface expression - Homo sapiens
input	[Complex:R-HSA-167636] CD28:Nef:Clathrin-coated Pit Adapter Protein Complex [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182280] Mechanism for down-regulation of CD28 by Nef
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex
output	[Complex:R-HSA-167631] CD28:Nef:Clathrin-coated Pit Adapter Protein [cytosol]
precedingEvent	[Reaction:R-HSA-167633] Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167637
summation	[Summation:200894] Once Nef has induced endocytosis of CD28, CD28 containing ve...

(hasEvent)

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