Reactome | G-protein alpha subunit is inactivated

Schema > Reaction > Entries

G-protein alpha subunit is inactivated Show undefined attributes

authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:167406] GTPase activity of G-protein alpha (q/11/14/15) [plasma membrane]
category	transition
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:167422] Jassal, Bijay, 2005-10-18
dbId	167415
displayName	G-protein alpha subunit is inactivated
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
eventOf	[Pathway:R-HSA-202040] G-protein activation - Homo sapiens
followingEvent	[Reaction:R-HSA-167433] G-protein beta-gamma subunits rebind the alpha-GDP subunit - Homo sapiens
input	[Complex:R-HSA-167438] G protein alpha:GTP complex [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:374843] Mechanism of GTP hydrolysis by G-protein alpha subunits [LiteratureReference:374813] Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	G-protein alpha subunit is inactivated
orthologousEvent	[Reaction:R-SCE-167415] G-protein alpha subunit is inactivated - Saccharomyces cerevisiae [Reaction:R-SPO-167415] G-protein alpha subunit is inactivated - Schizosaccharomyces pombe [Reaction:R-DDI-167415] G-protein alpha subunit is inactivated - Dictyostelium discoideum [Reaction:R-CEL-167415] G-protein alpha subunit is inactivated - Caenorhabditis elegans [Reaction:R-DME-167415] G-protein alpha subunit is inactivated - Drosophila melanogaster [Reaction:R-DRE-167415] G-protein alpha subunit is inactivated - Danio rerio [Reaction:R-RNO-167415] G-protein alpha subunit is inactivated - Rattus norvegicus [Reaction:R-GGA-167415] G-protein alpha subunit is inactivated - Gallus gallus [Reaction:R-XTR-167415] G-protein alpha subunit is inactivated - Xenopus tropicalis [Reaction:R-SSC-167415] G-protein alpha subunit is inactivated - Sus scrofa [Reaction:R-BTA-167415] G-protein alpha subunit is inactivated - Bos taurus [Reaction:R-CFA-167415] G-protein alpha subunit is inactivated - Canis familiaris [Reaction:R-MMU-167415] G-protein alpha subunit is inactivated - Mus musculus
output	[Complex:R-HSA-111864] G-protein alpha:GDP [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
precedingEvent	[Reaction:R-HSA-112271] The receptor:G-protein complex dissociates - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167415
summation	[Summation:167423] Slow intrisinc GTPase activity results in an inactivation of...

Referrals

(hasEvent)	[Pathway:R-HSA-202040] G-protein activation
(precedingEvent)	[Reaction:R-HSA-167433] G-protein beta-gamma subunits rebind the alpha-GDP subunit