Reactome | Formation of the P-TEFb(Cyclin T1:Cdk9) complex

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167236] Matthews, L, 2005-10-13 20:01:32
dbId	167235
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Formation of the P-TEFb(Cyclin T1:Cdk9) complex
eventOf	[Pathway:R-HSA-176034] Interactions of Tat with host cellular proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-167234] Association of Tat with P-TEFb(Cyclin T1:Cdk9) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-51611] CCNT1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-51801] CDK9 [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:167810] TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines [LiteratureReference:167873] A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of the P-TEFb(Cyclin T1:Cdk9) complex
output	[Complex:R-HSA-167183] P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167235
summation	[Summation:167808] Tat associates with the Cyclin T1 subunit of the cellular ki...

(hasEvent)	[Pathway:R-HSA-176034] Interactions of Tat with host cellular proteins
(precedingEvent)	[Reaction:R-HSA-167234] Association of Tat with P-TEFb(Cyclin T1:Cdk9)

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