Reactome | WNT binds to FZD and LRP5/6

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WNT binds to FZD and LRP5/6 Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1458874] Rothfels, K, 2011-07-22
dbId	1458875
displayName	WNT binds to FZD and LRP5/6
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
followingEvent	[Reaction:R-HSA-1504188] FZD recruits DVL to the receptor complex - Homo sapiens
inferredFrom	[Reaction:R-NUL-1458871] mFz8CRD binds LRP6N in vitro - Homo sapiens
input	[DefinedSet:R-HSA-1504202] canonical FZD receptors [plasma membrane] [DefinedSet:R-HSA-1504197] canonical WNTs [extracellular region] [CandidateSet:R-HSA-201719] LRP5/6 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1458867] LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way [LiteratureReference:517401] LDL-receptor-related proteins in Wnt signal transduction [LiteratureReference:1226055] Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 [LiteratureReference:208391] Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP [LiteratureReference:3238089] The way Wnt works: Components and mechanism [LiteratureReference:208137] Ligand receptor interactions in the Wnt signaling pathway in Drosophila [LiteratureReference:3769236] LDL-receptor-related protein 6 is a receptor for Dickkopf proteins [LiteratureReference:3769258] Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6 [LiteratureReference:3238086] Structural basis of Wnt recognition by Frizzled [LiteratureReference:5323470] structural Studies of Wnts and identification of an LRP6 binding site
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WNT binds to FZD and LRP5/6
output	[Complex:R-HSA-1458876] WNT:FZD:LRP5/6 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-3772461] Negative regulation by 'KRM:DKK:LRP5/6 [plasma membrane]' [NegativeRegulation:R-HSA-3772464] Negative regulation by 'SOST:LRP5/6 [plasma membrane]' [NegativeRegulation:R-HSA-8981509] Negative regulation by 'WIF1:WNT [extracellular region]' [NegativeRegulation:R-HSA-8981513] Negative regulation by 'WNT3A:sFRP [extracellular region]'
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1458875
summation	[Summation:1458858] The canonical WNT signaling pathway is initiated when WNT li...

Referrals

(hasEvent)	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT
(precedingEvent)	[Reaction:R-HSA-1504188] FZD recruits DVL to the receptor complex
(inferredTo)	[Reaction:R-NUL-1458871] mFz8CRD binds LRP6N in vitro

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