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Intrinsic Pathway of Fibrin Clot Formation
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authored
[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
crossReference
[DatabaseIdentifier:12325386] BioModels Database:BIOMD0000000338
[DatabaseIdentifier:12325388] BioModels Database:BIOMD0000000340
[DatabaseIdentifier:12325398] BioModels Database:BIOMD0000000339
dbId
140837
displayName
Intrinsic Pathway of Fibrin Clot Formation
edited
[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf
[Pathway:R-HSA-140877] Formation of Fibrin Clot (Clotting Cascade) - Homo sapiens
figure
[Figure:158319] /figures/intrinsic_path.jpg
goBiologicalProcess
[GO_BiologicalProcess:23206] blood coagulation, intrinsic pathway
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-158354] kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer - Homo sapiens
[Reaction:R-HSA-158218] prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer - Homo sapiens
[Reaction:R-HSA-158251] prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer - Homo sapiens
[Reaction:R-HSA-158311] kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin - Homo sapiens
[Reaction:R-HSA-158313] factor XII -> factor XIIa - Homo sapiens
[Reaction:R-HSA-158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - Homo sapiens
[Reaction:R-HSA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Homo sapiens
[Reaction:R-HSA-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Homo sapiens
[BlackBoxEvent:R-HSA-9670673] FIX is secreted - Homo sapiens
[Reaction:R-HSA-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Homo sapiens
[BlackBoxEvent:R-HSA-9661625] FVIII is secreted - Homo sapiens
[Reaction:R-HSA-158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - Homo sapiens
[Reaction:R-HSA-9015379] Factor IIa inhibitors (compounds) binds IIa - Homo sapiens
[Reaction:R-HSA-9603302] Factor IIa inhibitors (peptide) binds IIa - Homo sapiens
[Reaction:R-HSA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - Homo sapiens
[Reaction:R-HSA-5607043] factor VIIIa associates with cell membrane - Homo sapiens
[Reaction:R-HSA-5607023] factor IXa associates with cell membrane - Homo sapiens
[Reaction:R-HSA-158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa - Homo sapiens
[Reaction:R-HSA-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) - Homo sapiens
[Reaction:R-HSA-9670014] Factor VIIIa dissociates - Homo sapiens
[BlackBoxEvent:R-HSA-9650473] SERPING1 is secreted - Homo sapiens
[Reaction:R-HSA-158399] kallikrein binds SERPING1 - Homo sapiens
[Reaction:R-HSA-158357] factor XIIa binds SERPING1 - Homo sapiens
[Reaction:R-HSA-158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:140839] Tissue factor pathway inhibitor and the revised theory of coagulation
[LiteratureReference:140914] The coagulation cascade: initiation, maintenance, and regulation
[LiteratureReference:158226] Platelets and thrombin generation
[LiteratureReference:158249] The physiologic basis of assembly and activation of the plasma kallikrein/kinin system
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Intrinsic Pathway of Fibrin Clot Formation
Generation of intrinsic Factor X activating complex
orthologousEvent
[Pathway:R-MMU-140837] Intrinsic Pathway of Fibrin Clot Formation - Mus musculus
[Pathway:R-RNO-140837] Intrinsic Pathway of Fibrin Clot Formation - Rattus norvegicus
[Pathway:R-CFA-140837] Intrinsic Pathway of Fibrin Clot Formation - Canis familiaris
[Pathway:R-BTA-140837] Intrinsic Pathway of Fibrin Clot Formation - Bos taurus
[Pathway:R-SSC-140837] Intrinsic Pathway of Fibrin Clot Formation - Sus scrofa
[Pathway:R-DRE-140837] Intrinsic Pathway of Fibrin Clot Formation - Danio rerio
[Pathway:R-XTR-140837] Intrinsic Pathway of Fibrin Clot Formation - Xenopus tropicalis
[Pathway:R-GGA-140837] Intrinsic Pathway of Fibrin Clot Formation - Gallus gallus
[Pathway:R-DME-140837] Intrinsic Pathway of Fibrin Clot Formation - Drosophila melanogaster
[Pathway:R-CEL-140837] Intrinsic Pathway of Fibrin Clot Formation - Caenorhabditis elegans
releaseDate
2004-10-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165091] Rush, MG, 2008-01-11 00:00:00
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-140837
summation
[Summation:140838] The intrinsic pathway of blood clotting connects interaction...
Referrals
(hasEvent)
[Pathway:R-HSA-140877] Formation of Fibrin Clot (Clotting Cascade)
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