Reactome | Intrinsic Pathway of Fibrin Clot Formation

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Intrinsic Pathway of Fibrin Clot Formation Show undefined attributes

authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
crossReference	[DatabaseIdentifier:12325386] BioModels Database:BIOMD0000000338 [DatabaseIdentifier:12325388] BioModels Database:BIOMD0000000340 [DatabaseIdentifier:12325398] BioModels Database:BIOMD0000000339
dbId	140837
displayName	Intrinsic Pathway of Fibrin Clot Formation
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-140877] Formation of Fibrin Clot (Clotting Cascade) - Homo sapiens
figure	[Figure:158319] /figures/intrinsic_path.jpg
goBiologicalProcess	[GO_BiologicalProcess:23206] blood coagulation, intrinsic pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-158354] kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer - Homo sapiens [Reaction:R-HSA-158218] prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer - Homo sapiens [Reaction:R-HSA-158251] prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer - Homo sapiens [Reaction:R-HSA-158311] kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin - Homo sapiens [Reaction:R-HSA-158313] factor XII -> factor XIIa - Homo sapiens [Reaction:R-HSA-158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - Homo sapiens [Reaction:R-HSA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Homo sapiens [Reaction:R-HSA-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9670673] FIX is secreted - Homo sapiens [Reaction:R-HSA-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9661625] FVIII is secreted - Homo sapiens [Reaction:R-HSA-158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - Homo sapiens [Reaction:R-HSA-9015379] Factor IIa inhibitors (compounds) binds IIa - Homo sapiens [Reaction:R-HSA-9603302] Factor IIa inhibitors (peptide) binds IIa - Homo sapiens [Reaction:R-HSA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - Homo sapiens [Reaction:R-HSA-5607043] factor VIIIa associates with cell membrane - Homo sapiens [Reaction:R-HSA-5607023] factor IXa associates with cell membrane - Homo sapiens [Reaction:R-HSA-158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa - Homo sapiens [Reaction:R-HSA-158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) - Homo sapiens [Reaction:R-HSA-9670014] Factor VIIIa dissociates - Homo sapiens [BlackBoxEvent:R-HSA-9650473] SERPING1 is secreted - Homo sapiens [Reaction:R-HSA-158399] kallikrein binds SERPING1 - Homo sapiens [Reaction:R-HSA-158357] factor XIIa binds SERPING1 - Homo sapiens [Reaction:R-HSA-158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140839] Tissue factor pathway inhibitor and the revised theory of coagulation [LiteratureReference:140914] The coagulation cascade: initiation, maintenance, and regulation [LiteratureReference:158226] Platelets and thrombin generation [LiteratureReference:158249] The physiologic basis of assembly and activation of the plasma kallikrein/kinin system
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Intrinsic Pathway of Fibrin Clot Formation Generation of intrinsic Factor X activating complex
orthologousEvent	[Pathway:R-MMU-140837] Intrinsic Pathway of Fibrin Clot Formation - Mus musculus [Pathway:R-RNO-140837] Intrinsic Pathway of Fibrin Clot Formation - Rattus norvegicus [Pathway:R-CFA-140837] Intrinsic Pathway of Fibrin Clot Formation - Canis familiaris [Pathway:R-BTA-140837] Intrinsic Pathway of Fibrin Clot Formation - Bos taurus [Pathway:R-SSC-140837] Intrinsic Pathway of Fibrin Clot Formation - Sus scrofa [Pathway:R-DRE-140837] Intrinsic Pathway of Fibrin Clot Formation - Danio rerio [Pathway:R-XTR-140837] Intrinsic Pathway of Fibrin Clot Formation - Xenopus tropicalis [Pathway:R-GGA-140837] Intrinsic Pathway of Fibrin Clot Formation - Gallus gallus [Pathway:R-DME-140837] Intrinsic Pathway of Fibrin Clot Formation - Drosophila melanogaster [Pathway:R-CEL-140837] Intrinsic Pathway of Fibrin Clot Formation - Caenorhabditis elegans
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165091] Rush, MG, 2008-01-11 00:00:00
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-140837
summation	[Summation:140838] The intrinsic pathway of blood clotting connects interaction...

Referrals

(hasEvent)

[Pathway:R-HSA-140877] Formation of Fibrin Clot (Clotting Cascade)

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