Reactome | ER-Phagosome pathway

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ER-Phagosome pathway Show undefined attributes

authored	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
created	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
dbId	1236974
displayName	ER-Phagosome pathway
doi	10.3180/R-HSA-1236974.2
edited	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
eventOf	[Pathway:R-HSA-1236975] Antigen processing-Cross presentation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262909] antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1236947] Egress of internalized antigen to the cytosol via sec61 - Homo sapiens [BlackBoxEvent:R-HSA-1236935] Proteasomal cleavage of substrate - Homo sapiens [Reaction:R-HSA-8863914] Transport of SEC22B, TAP and PLC from ER to ERGIC - Homo sapiens [Reaction:R-HSA-8863858] SEC22B, CALR, STX4, TAP and TAPBP bind - Homo sapiens [Reaction:R-HSA-8951595] CALR, TAP, TAPBP dissociate from SEC22B:STX4 - Homo sapiens [Reaction:R-HSA-8863895] IKKB phosphorylates SNAP23 - Homo sapiens [BlackBoxEvent:R-HSA-8863973] Fusion of ERC and phagosome - Homo sapiens [Reaction:R-HSA-1236949] Translocation of antigenic peptides back to phagosomes via TAP - Homo sapiens [BlackBoxEvent:R-HSA-1236971] Peptide loading on MHC class I in phagosome - Homo sapiens [BlackBoxEvent:R-HSA-1236965] Export of peptide loaded MHC class I complex to PM - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1236402] Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens [LiteratureReference:1236405] ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells [LiteratureReference:1236473] Phagosomes are competent organelles for antigen cross-presentation [LiteratureReference:1236401] Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages [LiteratureReference:1236557] Intracellular mechanisms of antigen cross presentation in dendritic cells [LiteratureReference:1236491] The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum [LiteratureReference:1236477] The nature of the phagosomal membrane: endoplasmic reticulum versus plasmalemma [LiteratureReference:1236533] Quantitative and dynamic assessment of the contribution of the ER to phagosome formation [LiteratureReference:1236453] A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells [LiteratureReference:1236680] ER-mediated phagocytosis: myth or reality? [LiteratureReference:8864076] Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	ER-Phagosome pathway
orthologousEvent	[Pathway:R-GGA-1236974] ER-Phagosome pathway - Gallus gallus [Pathway:R-DRE-1236974] ER-Phagosome pathway - Danio rerio [Pathway:R-SSC-1236974] ER-Phagosome pathway - Sus scrofa [Pathway:R-BTA-1236974] ER-Phagosome pathway - Bos taurus [Pathway:R-CFA-1236974] ER-Phagosome pathway - Canis familiaris [Pathway:R-RNO-1236974] ER-Phagosome pathway - Rattus norvegicus [Pathway:R-MMU-1236974] ER-Phagosome pathway - Mus musculus
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295501] Desjardins, M, English, L, 2011-05-13 [InstanceEdit:8871418] Bergeron, JJ, 2016-05-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1236974
summation	[Summation:1236404] The other TAP-dependent cross-presentation mechanism in phag...

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(hasEvent)

[Pathway:R-HSA-1236975] Antigen processing-Cross presentation

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