Reactome | p-6Y-EGFR E746_A750del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1181209] Orlic-Milacic, Marija, 2011-01-31
dbId	1181214
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	p-6Y-EGFR E746_A750del [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [FragmentDeletionModification:9626687] Deletion of residues 746 to 750
inDisease	true
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
memberOf	[CandidateSet:R-HSA-1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9626688] Orlic-Milacic, Marija, 2018-10-29
name	p-6Y-EGFR E746_A750del Phosphorylated Epidermal Growth Factor Receptor E746_A750del p-6Y-EGFR Glu746_Ala750del
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1181214
startCoordinate	25

(hasMember)

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