Reactome | IN (Integrase) (P04585) protein [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HIV-175332] IN bound to sticky 3' ends of viral DNA [nucleoplasm] - Human immunodeficiency virus 1 [Complex:R-HSA-175247] Ku proteins bound to viral DNA [nucleoplasm] - Homo sapiens
created	[InstanceEdit:175576] Gopinathrao, G, 2006-02-23 23:50:37
dbId	175288
displayName	IN (Integrase) (P04585) protein [nucleoplasm]
endCoordinate	1435
goCellularComponent	[GO_CellularComponent:423007] host cell nucleoplasm
inDisease	false
modified	[InstanceEdit:9773515] Weiser, Joel, 2022-05-04
name	IN (Integrase) (P04585) protein
producedByEvent	[Reaction:R-HSA-164506] Gap repair completes provirus integration - Homo sapiens [Reaction:R-HSA-175117] 1-LTR circle formation - Homo sapiens [Reaction:R-HSA-164845] Suicidal integration leading to inverted circle formation - Homo sapiens [Reaction:R-HSA-175250] Suicidal integration leading to smaller circles of viral DNA - Homo sapiens [Reaction:R-HSA-175258] 2-LTR formation due to circularization of viral DNA - Homo sapiens
referenceEntity	[ReferenceGeneProduct:165325] UniProt:P04585 gag-pol
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:164493] Human immunodeficiency virus 1
stId	R-HIV-175288
startCoordinate	1148

(output)	[Reaction:R-HSA-175117] 1-LTR circle formation [Reaction:R-HSA-164506] Gap repair completes provirus integration [Reaction:R-HSA-175258] 2-LTR formation due to circularization of viral DNA [Reaction:R-HSA-164845] Suicidal integration leading to inverted circle formation [Reaction:R-HSA-175250] Suicidal integration leading to smaller circles of viral DNA
(activeUnit)	[CatalystActivity:175070] integrase activity of IN:viral DNA bound to host genomic DNA with staggered ends [nucleoplasm]
(hasComponent)	[Complex:R-HSA-175247] Ku proteins bound to viral DNA [nucleoplasm] [Complex:R-HIV-175332] IN bound to sticky 3' ends of viral DNA [nucleoplasm]