Reactome | alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+

Schema > Reaction > Entries

alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10562257] oxoglutarate dehydrogenase (NAD+) activity of OADH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10562259
displayName	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+
eventOf	[Pathway:R-GGA-71064] Lysine catabolism - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-71037] alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-70951] 2-OA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-70955] GL-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-71037
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-GGA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
(inferredTo)	[Reaction:R-HSA-71037] alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+

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