Reactome | CCR4-NOT complex deadenylates mRNA

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CCR4-NOT complex deadenylates mRNA Show undefined attributes

catalystActivity	[CatalystActivity:10587395] poly(A)-specific ribonuclease activity of CCR4-NOT Complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10587397
displayName	CCR4-NOT complex deadenylates mRNA
eventOf	[Pathway:R-GGA-429947] Deadenylation of mRNA - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-429978] Lsm1-7 Complex binds deadenylated mRNA - Gallus gallus [Reaction:R-GGA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Gallus gallus
inferredFrom	[Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-GGA-429989] Partially Deadenylated mRNA Complex [cytosol]
isInDisease	false
isInferred	true
name	CCR4-NOT complex deadenylates mRNA
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [DefinedSet:R-GGA-429842] eIF4A [cytosol] [EntityWithAccessionedSequence:R-GGA-72589] EIF4B [cytosol] [EntityWithAccessionedSequence:R-GGA-72578] EIF4E [cytosol] [EntityWithAccessionedSequence:R-GGA-72584] EIF4G1 [cytosol] [OtherEntity:R-ALL-429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol] [EntityWithAccessionedSequence:R-GGA-156803] PABPC1 [cytosol] [EntityWithAccessionedSequence:R-GGA-429861] PAIP1 [cytosol]
precedingEvent	[Reaction:R-GGA-430021] PAN2-PAN3 complex partially deadenylates mRNA - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-429955
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-429978] Lsm1-7 Complex binds deadenylated mRNA [Reaction:R-GGA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion
(hasEvent)	[Pathway:R-GGA-429947] Deadenylation of mRNA
(inferredTo)	[Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA